The Brain and its Mysteries

Here you will find the presentation slides provided by our talented presenter and neuro-science student Ethan Newnham. Etan is considered to be one of our local heros – he was recently interviewed by Glenys Grant for Eastsider News. The original article can be found on the Local Heros page and we were kindly granted permission to also publish it here:
Ethan Newnham interview by Glenys Grant for Eastsider News.


Contents

The Brain and Its Mysteries — Class Reunion — A Year in Oxford

1. Patient H. M.

2. Vision

3. Free Will

4. Why is your brain so good?

5. Mapping the Mind

6. The Experiment that Changed My Mind

7. Rewarding Experiments

8. Brain Myths


The Brain and Its Mysteries — Class Reunion September 2025 — A Year in Oxford

Presentation Slides:

“The Brain and its Mysteries – Oxford Special.pptx” (on Google Drive).

Ethan’s Message

I’ve attached the slides from my talk as always, but instead of writing notes on the slides like in most classes I thought it would be better to write a little summary of the year:

Michaelmas Term (Sept-Dec 2024):

– Arrived at Oxford and my home for the year: Brasenose College (the best College in Oxford)

– Met my incredible coursemates who came from all over the world to do this Master’s degree

– Applied to do my PhD at Oxford and Cambridge

– Started my classes, including lectures from world-renowned scientists

– Joined the trampolining and went to my first competition

– Ended the year with my first white Christmas!

Hilary Term (Jan-April 2025)

– Started my first research project, using optogenetics to understand how information is sent between the cortex and subcortex

– Won the Trampolining Varsity match against Cambridge, earning a Full Blue from Oxford

– Applied to lots of scholarships to try to fund my PhD

– Submitted my first thesis and presented my research at the Oxford neuroscience conference

Trinity Term (May – Sept 2025)

– Started my second research project, aiming to accelerate connectivity between neurons created from human stem cells

– Won the Oxford Fresher of the Year award for my results in trampolining

– After a long wait, I received funding to do my PhD at Oxford and Cambridge! I decided to stay with my lab in Oxford, so I’ll be heading back in 2 weeks to get started!

– Submitted my second thesis and completed my Viva Voce exam (thesis defense)

– Received my results and the Sherrington Prize in Neuroscience for the highest mark in my course

What a crazy year! Thank you for supporting me and coming along for the journey!

I tried to play an amazing video today but ran into some technical difficulties – here’s the link, it’s definitely worth a watch! https://www.youtube.com/watch?v=nzZ7EIIjXY4

Sending all of my gratitude and appreciation,

Ethan

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1. Patient H. M.

Presentation Slides:

More about Henry Molaison (Wikipedia)

Henry Gustav Molaison (February 26, 1926 – December 2, 2008), known widely as H.M., was an American who had a bilateral medial temporal lobectomy to surgically resect the anterior two thirds of his hippocampiparahippocampal corticesentorhinal corticespiriform cortices, and amygdalae in an attempt to cure his epilepsy. Although the surgery was partially successful in controlling his epilepsy, a severe side effect was that he became unable to form new memories. His unique case also helped define ethical standards in neurological research, emphasizing the need for patient consent and the consideration of long-term impacts of medical interventions.

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2. Vision

Presentation Slides:

Summary: The Brain and its Mysteries – Vision

Hubel anad Weisel after winning their Nobel Prize, 1981. Courtesy of Harvard University Archives.

More about Hubel & Wiesel (Wikipedia)

David Hunter Hubel FRS (February 27, 1926 – September 22, 2013) was an American Canadian neurophysiologist noted for his studies of the structure and function of the visual cortex. He was co-recipient with Torsten Wiesel of the 1981 Nobel Prize in Physiology or Medicine (shared with Roger W. Sperry), for their discoveries concerning information processing in the visual system.

Torsten Nils Wiesel (born 3 June 1924) is a Swedish neurophysiologist. With David H. Hubel, he received the 1981 Nobel Prize in Physiology or Medicine, for their discoveries concerning information processing in the visual system; the prize was shared with Roger W. Sperry for his independent research on the cerebral hemispheres.

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3. Free Will

Summary: The Brain and its Mysteries – Free Will

Presentation Slides:

Prompted by an audience question, we also talked about Brain Computer Interfaces, specifically the Synchron Brain Computer Interface (YouTube video).

On several different levels, from neurotransmitters through neuron firing rates to overall activity, the brain seems to “ramp up” before movements. This image depicts the readiness potential (RP), a ramping-up activity measured using EEG. The onset of the RP begins before the onset of a conscious intention or urge to act. Some have argued that this indicates the brain unconsciously commits to a decision before consciousness awareness. Others have argued that this activity is due to random fluctuations in brain activity, which drive arbitrary, purposeless movements.

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4. Why is your brain so good?

Summary: The Brain and its Mysteries – Why is your brain so good?

Microelectrode arrays

Microelectrode arrays (MEAs) (also referred to as multielectrode arrays) are devices that contain multiple (tens to thousands) microelectrodes through which neural signals are obtained or delivered, essentially serving as neural interfaces that connect neurons to electronic circuitry.
https://en.wikipedia.org/wiki/Microelectrode_array

Picture: By Dr. Steven M. Potter (via email), Fair use, https://en.wikipedia.org/w/index.php?curid=20518256

An in vitro MEA

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5. Mapping the Mind

Presentation Slides:

Navigate a 3D model of The Brain Dictionary.

Summary: The Brain and its Mysteries – Mapping The Mind

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6. The Experiment that Changed My Mind

Summary: The Brain and its Mysteries – The Experiment that Changed My Mind.

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7. Rewarding Experiments

Presentation Slides:

Summary: The Brain and its Mysteries – Rewarding Experiments

A re-enactment of the discovery of self-stimulation in 1954. Left to right: Seth Sharpless, Peter Milner, Jim Olds. The rat is being placed in a box with a runway to test its tendency to return to the place where it previously received stimulation.

Peter Milner (13 June 1919 – 2 June 2018) was a British-Canadian neuroscientist.

He worked at the UK’s Air Defence Research and Development Establishment before moving to Canada in 1944. He was an electrical engineer, but became interested in neuroscience while his wife Brenda Milner was studying the subject at McGill University; he became a graduate student under the same supervisor as she, and later taught at McGill himself. In collaboration with James Olds, he is credited with the discovery of the pleasure centre and the pain centre in the rat brain.

In his 1974 article “A Model for Visual Shape Recognition” Milner mentions a popular hypothesis suggesting that the features of individual objects are bound/segregated via synchronization of the activity of different neurons in the cortex. The theory, called binding-by-synchrony (BBS), is hypothesized to occur through the transient mutual synchronization of neurons located in different regions of the brain when the stimulus is presented.

Milner received the Gold Medal for Distinguished Lifetime Contributions to Canadian Psychology from the Canadian Psychological Association in 2005.

James Olds (May 30, 1922 – August 21, 1976) was an American psychologist who co-discovered the pleasure center of the brain with Peter Milner while he was a postdoctoral fellow at McGill University in 1954. He is considered to be one of the founders of modern neuroscience and received numerous distinctions ranging from election to the United States National Academy of Sciences to the Newcomb Cleveland Prize of the American Association for the Advancement of Science.

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8. Brain Myths

Presentation Slides:

Summary: The Brain and its Mysteries – Brain Myths

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